Answer:
Due ototoxicity and nephrotoxicity, the doses of these antimicrobials should be very well defined and monitored.
Explanation:
Aminoglycosides are antimicrobials used primarily to treat patients with severe infections caused by aerobic gram-negative bacteria. The main representatives of current use are gentamicin, amikacin, streptomycin and tobramycin. They are bactericidal and all have similar efficacy. With the development of less toxic antimicrobials, the use of Aminoglycosides has been contested. However, due to their proven efficacy, rare development of bacterial resistance, low risk of allergies and low cost, they continue to be widely used, especially in the treatment of hospitalized patients with severe infections. Because of ototoxicity and nephrotoxicity, the doses of these antimicrobials should be very well defined, and their potential toxic effects should be monitored throughout treatment.
This type of antibiotics requer some attention, once they have limited tissue distribution, depend for renal excretion and have a tight terapeutic index. So to make sure of the safety and efficacy of this drug, we need to monitore the peak and trough level.
