Numerous degenerative neurological conditions, most notably Parkinson's disease, have been linked to an excessive buildup of alpha synuclein (a-syn) in the brain. Intraneuronal inclusions, often known as Lewy bodies, are neuropathological characteristics seen in Parkinson's disease, Lewy body dementia, and other synucleopathies. The aggregation of a-syn is their main structural component. A-syn accumulation, aggregation, and ensuing Lewy body formation can be attributed to a variety of biological processes. These include genetic changes in parkin, synuclein, or the deubiquitinating enzyme ubiquitin C-terminal hydrolase (UCH-L1), which results in less efficient removal of a-syn via the ubiquitin proteasomal pathway (UPP). Additionally, environmental variables and an age-related decline in antioxidant defense mechanisms that heighten oxidative stress and can have an impact on the formation or clearance of a-syn are intracellular insults.
We focused on changes in the aggregation and clearance of a-syn as impacted by the UPP and the oxidative stress pathways in our dynamic models of a-syn processing in both normal and various disease states. A free radical profile similar to that observed in vivo after exposure to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is produced during simulation of enhanced oxidative stress (MPTP). To replicate the kinetics of a-syn that correlates to the neuropathology reported for the sporadic and hereditary types of Parkinson's disease, different model parameters of oxidative stress, UPP failure, or both routes are used. With the use of this in silico model, it is possible to evaluate the kinetics of pathway elements and more accurately identify and validate key pharmaceutical targets.
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Answer: Literally everywhere. Having an at least basic level of science helps you in day-to-day situations. For example, cooking. Not only is it crucial to understand the chemical and physical processes when cooking, you should also understand the complexity of how these micro and macromolecule exchange processes affect you and your body. Another prime example is your health, or human processes. You might not realize this, but your body is a plethora of complex, interconnected systems and networks that work hard 24/7 to maintain homeostasis (keep you alive). Understanding how our human physiques conduct themselves helps us gain the knowledge to be able to stay alive.
A eukaryotic chromosome consists of histones.
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Properties of eukaryotic chromosome</h3>
Eukaryotes posses pairs of linear of chromosomes and they are all contained in the nucleus of the cell, possessing characteristic forms.
Eukaryotic chromosomes consists of histones which are condensed and DNA surrounding nuclear proteins.
Therefore, a eukaryotic chromosome consists of histones.
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Answer:
A is the correct answer.
Explanation:
A vulture does eat dead animals but it itself is not classified as a decomposer due to the fact that the remains of most of the animal is still there.
