Earth is always rotating around the sun that means if it were winter on one side of the world, (that is not on the side of the sun) the other side of the world would be summer, ( the side that the sun is shining on)
<span>bones and footprints preserved in stone are examples of fossils. Fossils hardened animal remains such as shells, bones, and teeth.</span> That is the best i can come up with. Hope it helps any.
Answer and Explanation:
The Huntington disease is caused by a mutation in the gene that codifies for the Huntingtin protein (Htt). The mutation produces an altered form of the protein leading to the neuron´s death in certain areas of the brain.
The Huntington disease characterizes for being,
- Hereditary, passing from generation to generation. To express the disease, a person must have been born with an altered gene.
- Autosomal, affecting men and women equally, because the mutated gene is located on an autosomal chromosome.
- Dominant, which means that by getting only one copy of the altered gene coming from any of the parents, the receiving person will express the disease. The mutation in the gene dominates over the normal gene copy.
- Expressed by heterozygosis. Most people affected by the disease are heterozygous, with a normal copy and a mutated copy.
There are just a few cases all around the world (3% approximately) in which the disease is expressed with no family history. The progenitors are not affected by the mutation. These cases are very rare and are called <u>"de-novo" mutations.</u> A new mutation is spontaneously produced and it is not inherited from any of the parentals. It consists of an increase in the number of CAG repetitions. In a normal person, the number of CAG repetitions is less than 35. When there are 40 or more repetitions it occurs the disease. But when there are between 35 and 39 repetitions, the penetrance of the disease is incomplete. This is a "gray zone". Those alleles that fall in the gray zone are unstable and might produce the HD. Individuals with these unstable alleles have a tendency to increase the number of repetitions from generation to generation until the number reaches 40 repetitions and the person expresses the disease. This <u>usually occurs in the paternal germinal line</u>, as it is particularly unstable in sperm and probably meiosis greatly affects their instability, causing an increase in the number of CAG repeats.
Charles Darwin's evolutionary theory enables us to establish cause and effect in biology, including those associated with a person's overall character. The evolutionary biologist Theodosius Dobzhansky wrote: "Nothing in Biology Makes Sense Except in the Light of Evolution". It's a well-known statement on the evolutionary theory and their implications in all spheres of biology
