Self-esteem is how you feel about yourself, your own value and worth measured by yourself. Self-esteem is definitely affected by how others in life have treated you though,and what impression they gave to you on your worth, though not in every case, but in many.
Answer:
The Fc region of immunoglobulin E becomes bound to mast cells and basophils and when immunoglobulin's paratopes bind to an antigen, it causes the cells to release histamine and other inflammatory mediators.
Nicotine. Lol that’s the only one I know sorry