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9966 [12]
3 years ago
7

Chronic myeloid leukemia (CML) is a genetic disorder associated with the Philadelphia chromosome. The Philadelphia chromosome is

a mutation in chromosome 22. Part of chromosome 22 is exchanged with part of chromosome 9, bringing together two genes on chromosome 22 and causing a malignancy. What type of mutation occurs in the Philadelphia chromosome?
A.

duplication

B.

insertion

C.

inversion

D.

substitution

E.

translocation
Biology
2 answers:
stich3 [128]3 years ago
4 0

Answer:

E

Explanation:

melisa1 [442]3 years ago
3 0

<u>Answer:</u>

The correct answer option is E. translocation.

<u>Explanation:</u>

Philadelphia chromosome are CML and Philadelphia chromosome-positive ALL are the leukemias that are caused by a mutation.

This type of mutation which occurs in the  occurs in the Philadelphia chromosome is called translocation.

Philadelphia chromosome contains a fusion gene which consists of the ABL gene and the BCR gene, producing the BCR-ABL oncogene which has an enzyme with an abnormal tyrosine kinase activity.

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<em></em>

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<em>                    "No man is an island.” This saying is also true for organisms in an ecosystem. No organism exists in isolation.  Individual organisms live together in an ecosystem and depend on one another.  In fact, they have many different types of interactions with each other, and many of these interactions are critical for their survival. </em>

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