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9966 [12]
3 years ago
7

Chronic myeloid leukemia (CML) is a genetic disorder associated with the Philadelphia chromosome. The Philadelphia chromosome is

a mutation in chromosome 22. Part of chromosome 22 is exchanged with part of chromosome 9, bringing together two genes on chromosome 22 and causing a malignancy. What type of mutation occurs in the Philadelphia chromosome?
A.

duplication

B.

insertion

C.

inversion

D.

substitution

E.

translocation
Biology
2 answers:
stich3 [128]3 years ago
4 0

Answer:

E

Explanation:

melisa1 [442]3 years ago
3 0

<u>Answer:</u>

The correct answer option is E. translocation.

<u>Explanation:</u>

Philadelphia chromosome are CML and Philadelphia chromosome-positive ALL are the leukemias that are caused by a mutation.

This type of mutation which occurs in the  occurs in the Philadelphia chromosome is called translocation.

Philadelphia chromosome contains a fusion gene which consists of the ABL gene and the BCR gene, producing the BCR-ABL oncogene which has an enzyme with an abnormal tyrosine kinase activity.

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Answer:

transcription of mRNA from DNA

small ribosomal subunit binds to mRNA

initiation complex formed with addition of large ribosomal subunit

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peptide bond formation

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ribosomal subunits dissociate

Explanation:

The above describes the process of translation in the ribosome. After transcription of DNA to mRNA, the mRNA is taken to the ribosome to undergo translation, here the mRNA binds to the small ribosomal subuits and to other initiation factors; binding at the mRNA binding site on the small ribosomal subunit then the Large ribosomal subunits joins in.

Translation begins (codon recognition; initiating site) at the initiation codon AUG on the mRNA with the tRNA bringing its amino acid (methionine in eukaryotes and formyl methionine in prokaryotes) forming complementary base pair between its anticodon and mRNA's AUG start codon. Then translocation occurs with the ribosome moving one codon over on the mRNA thus moving the start codon tRNA from the A site to the P site, then codon recognition occurs (non-initiating site again) which includes incoming tRNA with an anticodon that is complementary to the codon exposed in the A site binds to the mRNA.

Then peptide bond formation occurs between the amino acid carried by the tRNA in the p site and the A site. When the ribosome reads a stop codon, the process stops and the polypeptide chain produced is released and the ribosomal subunits dissociates.

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