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9966 [12]
3 years ago
7

Chronic myeloid leukemia (CML) is a genetic disorder associated with the Philadelphia chromosome. The Philadelphia chromosome is

a mutation in chromosome 22. Part of chromosome 22 is exchanged with part of chromosome 9, bringing together two genes on chromosome 22 and causing a malignancy. What type of mutation occurs in the Philadelphia chromosome?
A.

duplication

B.

insertion

C.

inversion

D.

substitution

E.

translocation
Biology
2 answers:
stich3 [128]2 years ago
4 0

Answer:

E

Explanation:

melisa1 [442]3 years ago
3 0

<u>Answer:</u>

The correct answer option is E. translocation.

<u>Explanation:</u>

Philadelphia chromosome are CML and Philadelphia chromosome-positive ALL are the leukemias that are caused by a mutation.

This type of mutation which occurs in the  occurs in the Philadelphia chromosome is called translocation.

Philadelphia chromosome contains a fusion gene which consists of the ABL gene and the BCR gene, producing the BCR-ABL oncogene which has an enzyme with an abnormal tyrosine kinase activity.

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