to a scientist and asked him for his secret formula but he said I had to do the ravioli dance first before I got to see it and I made a fool of myself and died that morning
Long-term potentiation (LTP) is considered a cellular correlate of learning and memory. The presence of G protein-activated inwardly rectifying K(+) (GIRK) channels near excitatory synapses on dendritic spines suggests their possible involvement in synaptic plasticity. However, whether activity-dependent regulation of channels affects excitatory synaptic plasticity is unknown. In a companion article we have reported activity-dependent regulation of GIRK channel density in cultured hippocampal neurons that requires activity oF receptors (NMDAR) and protein phosphatase-1 (PP1) and takes place within 15 min. In this study, we performed whole-cell recordings of cultured hippocampal neurons and found that NMDAR activation increases basal GIRK current and GIRK channel activation mediated by adenosine A(1) receptors, but not GABA(B) receptors. Given the similar involvement of NMDARs, adenosine receptors, and PP1 in depotentiation of LTP caused by low-frequency stimulation that immediately follows LTP-inducing high-frequency stimulation, we wondered whether NMDAR-induced increase in GIRK channel surface density and current may contribute to the molecular mechanisms underlying this specific depotentiation. Remarkably, GIRK2 null mutation or GIRK channel blockade abolishes depotentiation of LTP, demonstrating that GIRK channels are critical for depotentiation, one form of excitatory synaptic plasticity.
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The net force is the vector sum of all the forces that act upon an object. That is to say, the net force is the sum of all the forces,
Answer:the largest taxon is kingdom and it is divided into phylum class order genus species
Explanation:
Plasticity is most adaptive when the environment change <u>Slowly and predictably </u>throughout an organism's life.
The ability of individual genotypes to create various phenotypes when exposed to various environmental situations is known as phenotypic plasticity. Here, the emphasis is on the role of plasticity in evolution rather than the evolution of plasticity itself, i.e., the evolution of phenotypic traits and organismal variety through plasticity. Phenotypic plasticity is a crucial characteristic of developmental systems that enables the organism to deal with environmental variability and/or unpredictability, although its significance for adaptive evolution is still debated.
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