Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
#SPJ4
Answera. use site specific recombination to incorporate their genome into the host genome for prophage replication until the host's growth is threatened.
Explanation:
A temperate phage is a bacteriophage which incorporate it's genome inside the host organism. It replicates it's own genome within the host cell. It basically uses the site specific recombination so as to incorporate the genome within the host cell.
Answer: Cells
Explanation:
The body has levels of organization that build on each other. Cells make up tissues, tissues make up organs, and organs make up organ systems. The function of an organ system depends on the integrated activity of its organs.
Answer:
Usually by age 18 is when you’re body fully developed.
Explanation:
Electron microscope is your answer
