Manic depression, also known as bipolar disorder is connected to varying episodes of mood swings. This could range from low to manic high levels of a change in mood. The main cause of this discover has not been uncovered, however it is known to be as a result of a combination of alteration of the brain structure, environment, and genetics. Chemistry is also known to sometimes play a role in this disorder. People who suffer from manic depression can have periods when they are energized and happy and other periods when they feel very sluggish, hopeless, and sad.