The kind of relationship in which one organism benefits to the detriment of the other is called parasitism. The parasites feeds on the other organism and it derives nourishment and nutrient from it. The host or the other organism suffers and does not benefit from the relationship. This relationship can lead to the eventual death of the host organism. Example is tapeworm and man.
The sickle form of the hemoglobin gene is created when an adenine nucleotide is changed to a thymine. ... That single amino acid replacement in the -globin protein alters the shape and the chemistry of the hemoglobin molecule, causing it to polymerize and distort the red blood cell into the sickle shape.