Please provide more context.
The first line of defense of the immune system includes mechanical barriers that prevent organisms from the body. The second line of defense includes processes that help remove or neutralize organisms that have penetrated mechanical barriers. The third line of defense is a complex defense that recognizes and reacts to specific organisms.
Answer:
The major ligaments of the ankle are: the anterior tibiofibular ligament, which connects the tibia to the fibula; the lateral collateral ligaments, which attach the fibula to the calcaneus and gives the ankle lateral stability; and, on the medial side of the ankle, the deltoid ligaments, which connect the tibia to the talus and calcaneus and provide medial stability.
