I don't know what the 1.6 means but if an individuals skin has a rash,itching or bubbling these should be reported or one should see a doctor, these can be a cause of a allergy or wrong medication.
When your body develops a tolerance for a medication the body gets used to it being there thus making the medication ineffective.
Explanation; Green, the mixture of blue and yellow, can be seen everywhere and in countless shades. In fact, the human eye sees green better than any color in the spectrum.