I’m pretty sure that the answer is a
You can't write a TV show in 10 sentences.
This is an intriguing premise, though. Looking forward to everyone's answers, and I might write one myself.
The lack of natural resources affected Mesopotamians because of no wood they had to make their homes out of mud bricks which did not hold up well. Also because they had no mountains or natural barriers they were often invaded. They had to make walls out of mud too. They were able to trade with the surplus of grain they grew for things that they needed.