<span>achieve a therapeutic objective (cure disease, mitigate symptoms etc.)
minimize toxicity
minimize difficulty of administration
identify dosing regimens</span>List the goals of drug therapytherapeutic window/rangethe plasma concentration range that is effective and safe in treating specific diseasestrue(T,F): The therapeutic response is dependent on drug achieving an adequate plasma concentrationmultiple doses________ are given to stay in the therapeutic windowvolume of distribution (V)<span>an important indicator of the extent of drug distribution into body fluids and tissues
relates the amount of drug in the body to the measured concentration in the plasma
it is the volume required to account for all of the drug in the body if the concentration in all tissues is the same as the plasma tissue.</span>clearancethe process of removing a drug from plasma (expressed as volume of plasma per a given unit of time)true(T,F): Clearance indicates the volume of plasma (or blood) from which the drug is completely removed, or cleared, in a given time period.half-life<span>volume of distribution and clearance influences the _______ of a drug.
Dosing regimen: How often?</span>oral bioavailability<span>clearance and absorption influences the ________ of a drug
Dosing regimen: How much?</span>steady statethe amount of drug administered is equal to the amount of drug eliminated within one dosing interval resulting in a plateau or constant serum drug levelshortDrugs with a _____ half-life reach steady state rapidlylongDrugs with a ____ half-life take days to weeks to reach steady statetherapeutic windowA steady state is desired within the _________half-lifethe time necessary for the concentration of drug in the plasma to decrease by one-half (50%)about 5How many half-lives are required to reach steady state?loading dosesoften administered at the initiation of an infusion to achieve an immediate therapeutic plasma concentration of the drug (allows rapid achievement of therapeutic serum)true(T,F): The same loading dose is used regardless of metabolism/elimination dysfunction
Answer:
Immune reaction.
Explanation:
Plasma cell disorders are generally uncommon. They begin at that time when a single plasma cell multiplies excessively. This results in a group of genetically identical cells (called a clone), which produces a large quantity of a single type of antibody (immunoglobulin). Plasma cells develop from B cells (B lymphocytes), which is a type of white blood cell that usually produces antibodies. These proteins help the body to fight against infection. This means they help in the immune system.
In plasma cell disorders, one clone of plasma cells repeatedly multiply, which can’t be controlled. As a result, these clone creates a vast amount of a single antibody (monoclonal antibody) which is known as the M-protein. In some cases (such as with monoclonal gammopathies), the antibody produced remains incomplete, consisting of only light chains or heavy chains (fully functional antibodies usually comprised of two pairs of two different chains called a light chain and heavy chain). The abnormal plasma cells and the antibodies which they produce are limited to one type, and levels of other kinds of antibodies that help in the fight against infections start falling.
People with plasma cell disorders are often at higher risk of infections than others. So, from this discussion, we can say that plasma cell disorder affects the immune system.
