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goblinko [34]
3 years ago
9

A variation of the acetamidomalonate synthesis can be used to synthesize threonine. The process involves the following steps: Et

hoxide ion deprotonates diethyl acetamidomalonate, forming enolate anion 1; Enolate anion 1 makes a nucleophilic attack on acetaldehyde, forming tetrahedral intermediate 2; Protonation of the oxyanion forms alcohol 3; Acid hydrolysis yields dicarboxyamino alcohol 4; Decarboxylation leads to the final amino acid. Write out the mechanism on a separate sheet of paper, and then draw the structure of tetrahedral intermediate 2.

Chemistry
1 answer:
ipn [44]3 years ago
7 0

Answer:

See figure 1

Explanation:

For this reaction, we have the production of a carbanion as the first step. The base "ethoxide" can remove a hydrogen-producing a negative charge in the carbon (<u>enolate anion 1</u>). Then this negative charge can attack the carbon of the carbonyl group in the molecule acetaldehyde and the <u>tetrahedral intermediate 2</u> is form. In the next step, we have the protonation of the oxygen to produce <u>alcohol 3</u>. A continuation we have the hydrolysis of the ester groups to produce the <u>Dicarboxyamino alcohol</u> and finally, we have a decarboxylation reaction we will produce the amino acid <u>Threonine</u>.

To further explanations see figure 1

I hope it helps!

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