Question

In the synthesis of thyroid hormones, iodine is attached to tyrosine amino acids in colloid, initially forming what two products?

Answer 1

Answer:

the products formed are Monoiodotyrosine (MIT) and Diiodotyrosine (DIT)

Explanation:

Monoiodotyrosine (MIT) is a precursor of thyroid hormone and results from iodization of tyrosine at the meta- position of the phenol ring, and Diiodotyrosine (DIT) is a precursor in the production of thyroid hormone, and results from iodization of monoiodotyrosine at the other meta- position on the phenol ring.

Once inside the gland, the iodide is oxidized by a peroxidase to iodine and then bound to tyrosine, forming either monoiodotyrosine or diiodotyrosine. Both of these are then coupled enzymatically to form T4 or T3. The T3 and T4 are bound to the protein thyroglobulin and stored as colloid in the gland.