A food web is made up of two or more interconnected food chains.
<span>Coding sequences that regulate gene expression </span>
C. The scenario described when a 7 Tesla scanner, or 7T scanner is used instead of 3T scanner is, "when higher pixel resolution is required"
<h3>What is pixel resolution?</h3>
Pixels per inch and pixels per centimeter are measurements of the pixel density of an electronic image device, such as a computer monitor or television display, or image digitizing device such as a camera or image scanner.
A 7 Tesla scanner, or 7T scanner is preferable to a 3T scanner because the 7 Tesla scanner gives higher pixel resolution when compared to 3 Tesla scanner.
Thus, the scenario described when a 7 Tesla scanner, or 7T scanner is used instead of 3T scanner is, "when higher pixel resolution is required".
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Mosunetuzumab is a T-cell reliant bispecific antibody that binds to CD3 and CD20 to trigger T-cell mediated B-cell death.
However, cytokine release syndrome, which has the potential to limit dose and efficacy, can result from powerful immune stimulation with T-cell focused treatments.
We created a novel mechanistic model of immune and antitumor responses to the T-cell bispecifics (mosunetuzumab and blinatumomab), taking into account the dynamics of B- and T-lymphocytes in circulation, lymphoid tissues, and tumors, in order to better understand the mechanisms underlying safety and efficacy as well as to explore safety mitigation strategies.
Using mosunetuzumab nonclinical and blinatumomab clinical data, the model was created and validated. The initial step-fractionated dose was projected to minimize systemic T-cell activation and cytokine release without impairing tumour response.
Simulations described the mechanisms underlying the observed cell and cytokine (IL6) dynamics. The Phase I clinical study for mosunetuzumab was changed to a step-fractionated treatment schedule as a result of these findings, allowing for the safer administration of greater dosages.
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