Question

A ketone and a Grignard reagent react in ether solution followed by acid workup, to form a tertiary alcohol. Grignard reactions must be scrupulously dry in order to work effectively. A common method of drying glassware is to rinse with acetone prior to use.
1. Why is rinsing with acetone not suitable for the reaction stated in the question?a)Magnesium does not dissolve in acetone.b)Water dissolves in acetone. Adding acetone will add water to the reaction flask.c)Magnesium dissolves in acetone. Adding acetone will remove a vital reactant from the flask.d)Acetone is a ketone. Grignard reagents will react with acetone to make an unwanted byproduct.

Answer 1

Answer:The correct answer is "d"

Explanation:

Grignard reagent has a tendency to react with ketones.This reaction involves affect by the nucleophilic carbon atom present in the grignard reagent at carbonyl carbon atom to form a new C-C bond.Acidic work up converts the alkaloid species into corresponding alcohol,in this case mostly likely tertiary alcohol.

Mostly its is preferred to oven-dry all glasswares prior to starting experiment, at temperature above 100°C.