The major limitation is that C) he can not definitively show what causes the difference.
It may be caused by <em>something the people are doing</em> (if so, what?) or it may be caused by <em>some environmental differences</em> or a<em> combination of both</em>.
Answer is: <span>it comes at the right time.
Some of the chemistry discoveries that come in right time (with enough informations, knowledge and right technology to use that discovery) are: </span>Periodic Table of the Elements, discovery of electron, proton, neutron, radioactivity, pasteurization, t<span>he Haber-Bosch process.</span>
