1answer.
Ask question
Login Signup
Ask question
All categories
  • English
  • Mathematics
  • Social Studies
  • Business
  • History
  • Health
  • Geography
  • Biology
  • Physics
  • Chemistry
  • Computers and Technology
  • Arts
  • World Languages
  • Spanish
  • French
  • German
  • Advanced Placement (AP)
  • SAT
  • Medicine
  • Law
  • Engineering
Nookie1986 [14]
3 years ago
5

Lesch-Nyhan syndrome is an X-linked, recessive condition caused by mutation of the HPRT1 gene responsible for purine metabolism.

The syndrome is characterized by juvenile-onset gout, involuntary muscle movements, and behavioral disorders. A mother and father have a young daughter who was diagnosed with Lesch-Nyhan syndrome. No one in the father\'s family was ever diagnosed with the syndrome. The mother\'s maternal grandfather was diagnosed with Lesch-Nyhan syndrome, but neither one of her parents was diagnosed with the condition. Select all the descriptions that could explain how their daughter inherited Lesch-Nyhan syndrome.
A.The mother's X chromosomes failed to separate during meiosis, and the daughter inherited two X chromosomes with the Lesch-Nyhan mutation. The father contributed no sex chromosomes.

B. The father did not contribute a sex chromosome to his daughter due to nondisjunction of the sex chromosomes. The daughter is XO and her only X chromosome came from her mother, who was a carrier.

C.The daughter could not have inherited Lesch-Nyhan because neither of her parents have the disease. The fact that her great-grandfather had Lesch-Nyhan is a coincidence.

D. The daughter is XO. Her only X chromosome carries the Lesch-Nyhan mutation and was inherited from her father, who was a carrier.
Biology
1 answer:
Elanso [62]3 years ago
3 0

Answer:

B. The father did not contribute a sex chromosome to his daughter due to nondisjunction of the sex chromosomes. The daughter is XO and her only X chromosome came from her mother, who was a carrier.

A.The mother's X chromosomes failed to separate during meiosis, and the daughter inherited two X chromosomes with the Lesch-Nyhan mutation. The father contributed no sex chromosomes.

Explanation:

As seen in the question above, a little girl was diagnosed with Lesch-Nyhan syndrome, which is an X-linked recessive condition caused by a mutation in the HPRT1 gene responsible for purine metabolism.

The little girl's parents do not have the syndrome, and no one in the little girl's paternal family presented this syndrome, however, we know that the maternal grandfather of the little girl's mother had the syndrome, which means that it was the mother's genetic material that contributed to the development of the syndrome in the little girl. This was because the little girl did not receive any X chromosomes from her father, but she inherited the two X chromosomes from her mother that coded for the Lesch-Nyhan mutation. This happened because the mother's X chromosome disjuction did not occur during meiosis I.

As shown above, the father did not contribute any sex chromosomes to his daughter, which means that the daughter is XO and her only X chromosome came from her mother, who was a carrier.

You might be interested in
Which layers most likely have a pressure, represented in units of GPa, ranging from 75 GPa to 110 GPa? Check all that apply. Out
lara [203]
<h3><u>Answer;</u></h3>

Lithosphere

<h3><u>Explanation</u>;</h3>
  • Lithosphere is the solid outer part of the earth which includes the brittle upper portion of the crust and the mantle. It is bounded by the asthenosphere below and the atmosphere above.
  • <em><u>The pressure in the lithosphere is about 109 gigapascals or GPa.  </u></em>
  • <em><u>Asthenosphere has a pressure of about 18 GPa</u></em>
  • <em><u>The mantle is a layer between the outer core and the crust, it has a pressure of about 149 GPa.</u></em>
5 0
3 years ago
Read 2 more answers
4. Based on what you have discovered, which of the following conditions would lead to the formation of clouds?
ddd [48]
<span>a) Moist air moves up as it encounters a mountain range.</span>
3 0
3 years ago
Which best describes metabolism? A. all anabolic chemical reactions in the body B. all catabolic chemical reactions in the body
AVprozaik [17]

Answer:

C  I think

Explanation:

6 0
3 years ago
The two most important regulatory systems for the maintenance of homeostasis are
LenaWriter [7]
The Nervous System and The Endocrine System.
4 0
3 years ago
What does this mean?
saw5 [17]
What does what mean?
8 0
3 years ago
Other questions:
  • The 8 levels of classification, from broadest to most specific are:
    13·2 answers
  • Put in order from least complex (1) to most complex (4). atom, organ,tissue,cell
    8·1 answer
  • What is the difference between an epistatic gene and a hypostatic gene? an epistatic gene is dominant; a hypostatic gene is rece
    15·1 answer
  • Do polar Bears and American black bears share a common ancestor
    15·1 answer
  • 30 POINTS!! Select the correct answer from each drop-down menu.
    12·1 answer
  • Which is true about scientific knowledge?
    12·2 answers
  • What is released at each level of a pyramid of energy
    10·1 answer
  • What term defines a cell that contains a single set of chromosomes? Responses A. Cytokinesis B. Telophase C. Diploid D. Haploid
    11·1 answer
  • Why is ATP production Constant?
    10·1 answer
  • Which statement is supported by the two experiments?
    11·1 answer
Add answer
Login
Not registered? Fast signup
Signup
Login Signup
Ask question!