Lets look at the temperature of these regions. In the New England colonies it was typically colder, they were father North. In the Southern Colonies, it was generally warmer, and same for the Midwestern. Now the landscape of these colonies. In the New England colonies the soil was hard and rigid, due to the mountains in the are. The Southern Colonies had fertile soil and the Midwestern Colonies had forests. So, in the New England colonies is where more of the "factories" were, the Southern Colonies had the Agricultural, and the Midwest had the fur. Now, all these colonies were trading with other countries and were dependent on each other.
