Chemical change or process
Majority can such as hydrogen H and oxygen O forming water H2O but uranium having extra neutrons to form plutonium and beyond simply can't because it will not last for a fraction of a second or spiral out of control and violently react like the little boy and the fat man (a uranium and plutonium nuclear weapon) so yes and no
The head of the phospholipids molecule is attracted to water, the tail repels water
Your answer would be D, single replacement