The Spaniards practically went to war with the native Americans in South America, such as the Inca. They also brought diseases to South America. Diseases like smallpox.
Explanation:
Then after effectively killing off most of the native American population the Spanish continued to use South America for resources and they enslaved most of what was left of the non-Spanish and mixed populations. Francisco Pizarro took a page from Cortes' book, capturing Atahualpa, Emperor of the Inca, in 1532 and Cortes was the conquistador who defeated the Aztec Empire in what is now modern day Mexico or Central America.
