The answer to this question would be: resistance
When a patient developing a resistance to a certain drug, the same amount of doses will not exert the same effect as before. The effect will be lower, thus the doctor will need to increase the dose to increase the effect
I believe the correct answer is the second option. There will be two cobalt atoms in one formula unit of cobalt (III) oxide. It has a chemical formula of Co2O3. This compound is does not naturally occur so it is being synthesized. It is mostly used as bleaching agent.
When baking powder is added to a cake, the acid base reaction it undergoes with the acidic butter produces the carbon dioxide that makes the cake rise.