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<h3><u>Full Question:</u></h3>
The following compound has been found effective in treating pain and inflammation (J. Med. Chem. 2007, 4222). Which sequence correctly ranks each carbonyl group in order of increasing reactivity toward nucleophilic addition?
A) 1 < 2 < 3
B) 2 < 3 < 1
C) 3 < 1 < 2
D) 1 < 3 < 2
<h3><u>Answer: </u></h3>
The rate of nucleophilic attack of carbonyl compounds is 2<3 <1.
Option B
<h3><u>Explanation. </u></h3>
Nucleophilic attack is explained as the attack of an electron rich radical to a carbonyl compound like aldehyde or a ketone. A nucleophile has a high electron density, so it searches for a electropositive atom where it can donate a portion of its electron density and become stable.
A carbonyl compound is a hybridized carbon atom with a double bonded oxygen atom in it. The oxygen atom pulls a huge portion of electron density from carbon being very electropositive.
In a ketone, there are two factors that make it less likely to undergo a nucleophilic attack than aldehyde. Firstly, the steric hindrance of two carbon groups being attached with the carbonyl carbon makes it harder for the nucleophile to approach. Secondly, the electron push by the carbon groups attached makes the carbonyl carbon a bit less electropositive than the aldehyde one. So aldehydes are more reactive towards a nucleophilic addition reaction.
Answer:
Approximately .
Explanation:
Balanced equation for this reaction:
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Look up the relative atomic mass of elements in the limiting reactant, , as well as those in the product of interest, :
Calculate the formula mass for both the limiting reactant and the product of interest:
.
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Calculate the quantity of the limiting reactant () available to this reaction:
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Refer to the balanced equation for this reaction. The coefficients of the limiting reactant () and the product () are both . Thus:
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In other words, for every of formula units that are consumed, of formula units would (in theory) be produced. Thus, calculate the theoretical yield of in this experiment:
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Calculate the theoretical yield of this experiment in terms of the mass of expected to be produced:
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Given that the actual yield in this question (in terms of the mass of ) is , calculate the percentage yield of this experiment:
.