Does methylenecyclohexane obey Zaitsev's rule? why or why not
1 answer:
Answer:
Explanation: Zaitsev’s or Saytzev’s (anglicized spelling) rule is an empirical rule used to predict regioselectivity of 1,2-elimination reactions occurring via E1 mechanism or via E2 mechanism. It states that in a regioselective E1 or E2 reaction the major product is the more stable alkene, i.e., the alkene with the more highly substituted double bond.
E1 reaction always follow Zaitsev’s rule; with E2 reactions, there are exceptions (see antiperiplanar).
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Answer:
a. Gly-Lys + Leu-Ala-Cys-Arg + Ala-Phe
b. Glu-Ala-Phe + Gly-Ala-Tyr
Explanation:
In this case, we have to remember which peptidic bonds can break each protease:
-) <u>Trypsin</u>
It breaks selectively the peptidic bond in the carbonyl group of lysine or arginine.
-) <u>Chymotrypsin</u>
It breaks selectively the peptidic bond in the carbonyl group of phenylalanine, tryptophan, or tyrosine.
With this in mind in "peptide a", the peptidic bonds that would be broken are the ones in the <u>"Lis"</u> and <u>"Arg"</u> (See figure 1).
In "peptide b", the peptidic bond that would be broken is the one in the <u>"Phe"</u> (See figure 2). The second amino acid that can be broken is <u>tyrosine</u>, but this amino acid is placed in the <u>C terminal spot</u>, therefore will not be involved in the <u>hydrolysis</u>.
