A phosphate buffer is involved in the formation of urine. The developing urine contains H2PO4 and HPO42- in the same concentrati
1 answer:
Answer:
The ionization equation is
⇄
(1)
Explanation:
The ionization equation is
⇄
(1)
As the Bronsted definition sais, an acid is a substance with the ability to give protons thus, H2PO4 is the acid and HPO42- is the conjugate base.
The Ka expression is the ratio between the concentration of products and reactants of the equilibrium reaction so,
The pKa is
The pKa of H2CO3 is 6,35, thus this a stronger acid than H2PO4. The higher the pKa of an acid greater the capacity to donate protons.
In the body H2CO3 is a more optimal buffer for regulating pH due to the combination of the two acid-base equilibriums and the two pKa.
If the urine is acidified, according to Le Chatlier's Principle the equilibrium (1) moves to the left neutralizing the excess proton concentration.
You might be interested in
Answer:The product formed on reaction with hydroxide ion as nucleophile is 2R-hexane-2-ol.
The product formed on reaction with water would be a 50:50 mixture of
2S-hexane-2-ol. and 2R-hexane-2-ol.
Explanation:
2S-iodohexane on reactiong with hydroxide ion would undergo SN² substitution reaction that is substitution bimolecular. Hydroxide ion has a negative charge and hence it is a quite good nucleophile .
The rate of a SN² reaction depends on both the substrate and nucleophile . Here the substrate is a secondary carbon center having Iodine as a leaving group.SN² reaction takes place here as hydroxide ion is a good nucleophile and it can attack the secondary carbon center from the back side leading to the formation of 2R-hexane-2-ol.
In a SN² reaction since the the nucleophile attacks from the back-side so the product formation takes place with the inversion of configuration.
When the same substrate S-2-iodohexane undergoes a substitution reaction with water as a nucleophile then the reaction occurs through (SN¹) substitution nucleophilic unimolecular mechanism .
The rate of a SN¹ reaction depends only on the nature of substrate and is independent of the nature of nucleophile.
The SN¹ reaction is a 2 step reaction , in the first step leaving group leaves leading to the formation of a carbocation and once the carbocation is formed then any weaker nucleophile or even solvent molecules can attack leading the formation of products.
In this case a secondary carbocation would be generated in the first step and then water will attack this carbocation to form the product in the second step.
The product formed on using water as a nucleophile would be a racemic mixture of R and S isomers of hexane -2-ol in 50:50 ratio. The two products formed would be 2R-hexane-2-ol and 2S-hexane-2-ol.
Kindly refer the attachment for reaction mechanism and structure of products.
