Question

Match the cofactors below with their roles in the pyruvate dehydrogenase complex reaction.

Answer 1

Cofactors:
A. Coenzyme A (CoA-SH)
B. NAD+
C. Thiamine pyrophosphate (TPP)
D. FAD
E. Lipoic acid in oxidized form

Roles:
E... Attacks and attaches to the central carbon in pyruvate.
A...Oxidizes FADH2.
C...Accepts the acetyl group from reduced lipoic acid.
D... Oxidizes the reduced form of lipoic acid.
B... Initial electron acceptor in oxidation of pyruvate.