Stark contrast to paths on energy surfaces or even mechanistic reactions, rule-based and inductive computational approaches to reaction prediction mostly consider only overall transformations. Overall transformations are general molecular graph rearrangements reflecting only the net change of several successive mechanistic reactions. For example, Figure 1 shows the overall transformation of an alkene interacting with hydrobromic acid to yield the alkyl bromide along with the two elementary reactions which compose the transformation.
A, electrons are negatively charged and do orbit around the nucleons
The answers is an electrical force.
Under normal conditions, atoms interact with each other via electrons that are furthest away from the nucleus. These electrons from the what is called the outer shell of the atom, electrons from the outer shell that can participate in chemical reactions are called valence electrons.