Complete Question
The complete question is shown on the first uploaded image
Answer:
[S]<<KM | [S]=KM | [S]>>KM | Not true
____________ | Half of the active | Reaction rate is | Increasing
is about | sites are filled of | independent of |
will
equal to . | | [S] | lower KM
_____________________________________________|____________
[ES] is much | | Almost all active
lower than | | sites are filled
| |
Explanation:
Generally the combined enzyme is mathematically represented as
for Michaelis-Menten equation
Where is the substrate concentration and
is the Michaelis constant
Considering the statement
Looking at the equation is denominator so it can be ignored(it is far too small compared to
) hence the above equation becomes
Since is less than
it means that
so it means that
What this means is that the number of combined enzymes i.e the number of occupied site is very small compared to the the total sites
i.e the total enzymes concentration which means that the free sites [
i.e the concentration of free enzymes is almost equal to
Considering the second statement
So this means that equation one would now become
So this means that half of the active sites that is the total enzyme concentration are filled with S
Considering the Third Statement
In this case the in the denominator of equation 1 would be neglected and the equation becomes
This means that almost all the sites are occupied with substrate
The rate of this reaction is mathematically defined as
Where v is the rate of the reaction(also know as the velocity of the reaction at a given time t) and is he maximum velocity of the reaction
In this case also the at the denominator would be neglected as a result of the statement hence the equation becomes
So it means that the reaction does not depend on the concentration of substrate [S]
For the final statement(Not True ) it would match with condition that states that increasing will lower
This is because does not depend on enzyme concentration it is a property of a enzyme
