The atoms combine to form compounds to attain stability in nature. The combination of atoms takes place by sharing of electrons between the atoms or complete transfer of electrons from one atom to another. Generally, atoms combine to complete their octet, that is to possess eight electrons in their outer most shell (noble gas configurations) except hydrogen which can attain stability by two electrons in its outer most shell.
Since germanium has 4 electrons in its outer most shell so it needs 4 more electrons to complete its octet and attains the stability. Hydrogen has 1 electron in its outer most shell and it needs only 1 electron to attain stability so, each germanium will combine with 4 hydrogen atoms and thus forming
molecule which is stable in nature.
Hence,
is the formula of the hydride formed by germanium.
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Cyclic nucleotides cAMP and cGMP are part of almost all major cellular signaling pathways. Phosphodiesterases (PDEs) are enzymes that regulate the intracellular levels of cAMP and cGMP. Protein kinase A or cAMP-dependent protein kinase mediates most cAMP effects in the cell. Over the last 25 years, various components of this group of molecules have been involved in human diseases, both genetic and acquired. Lately, the PDEs attract more attention. The pharmacological exploitation of the PDE’s ability to regulate cGMP and cAMP, and through them, a variety of signaling pathways, has led to a number of new drugs for diverse applications from the treatment of erectile dysfunction to heart failure, asthma, and chronic obstructive pulmonary disease. We present the abstracts (available online) and selected articles from the proceedings of a meeting that took place at the National Institutes of Health (NIH), Bethesda, MD, June 8–10, 2011.
generally bacteria reproduce by binary fission