Question

How many equivalents of pyruvate are needed to generate 1 equivalent of glucose?

Answer 1

Gluconeogenesis is the process by which the body produce glucose from non-carbohydrate substrates such as pyruvate. To produce glucose from pyruvate, two moleucules of pyruvate is needed. The reaction for the gluconeogenesis reaction is as follow:
2 pyruvate + 4 ATP + 2 GTP + 2 NADH = Glucose + 4 ADP + 2 GDP + 2 NAD + 6Pi.