Question

Calcium carbonate interacts with omadacycline (Nuzyra). How should this interaction be avoided?(Interactions) hint look up omadacycline

Answer 1

Answer: An interaction is caused between the two medications (Calcium carbonate and Omadacycline) and causes serious negative side effects, due to the fact that when the two are taken together the body is unable to process the antibiotic therefore causing a reduction in the concentration of antiobiotics in the blood stream. this causes a reduction the body's ability to fight off the infection. In addition, drug interactions with calcium increase the risk of dangerously high calcium levels in the blood and disrupt the body´s basal state.

Explanation:

Omadacycline is a broad spectrum antibiotic. It belongs to the tetracycline group and specifically to the aminomethylcycline subclass and is used mainly in the treatment of  treatment of community-acquired bacterial pneumonia and acute skin and skin structure infections. the mecanism of action of Omadacycline works like every other tetracycline antiobiotic. It inhibits the bacterial protein synthesis thereby rendurig the bacteria useless and thus stopping the replicaton of these bacterias.

Calcium carbonate on the other hand, is usuallly administered as a dietary supplement when the corporal levels of calcium do not reach sufficient levels.  It may also be used as an antacid to relieve heartburn, acid indigestion, and nausea. It is available with or without a prescription and is available in many forms for example;  as a tablet, chewable tablet, capsule or as a liquid.

Calcium is vital for healthy bones, muscles, nervous system, and heart. Calcium is involved in cardiac muscle contraction and electrical impulse conduction.

When calcium carbonate is taken with Omadacycline causes a significant increase in the levels of calcium in the blood. Excess levels of calcium interfere with the absorption of the antibiotic  because calcium binds to the tetracycline in the intestine causing a reduction in the efectiveness. Failure to control the infection could lead to severe side effects whether temporary or permanent and in extreme cases death.

Calcium carbonate SHOULD NOT BE TAKEN WITH

• Bisphosphonates
• Fluoroquinolone antibiotics
• H2 blockers
• Proton pump inhibitors (PPIs)
• Tetracycline antiobiotics (Omadacycline- Nuzyra)
• Thiazide diuretics

In conclusion, calcium carbonate should not be taken with tetracycline antiobiotics in this case Omadacycline because it causes an ncrease in calcium levels which binds to the antibiotic therefore reducing its absorption by the intestine and reducing its effect in fighting off the infection. The antiobiotic should be taken two hours before the calcium carbonate or about four to six hours after.