1answer.
Ask question
Login Signup
Ask question
All categories
  • English
  • Mathematics
  • Social Studies
  • Business
  • History
  • Health
  • Geography
  • Biology
  • Physics
  • Chemistry
  • Computers and Technology
  • Arts
  • World Languages
  • Spanish
  • French
  • German
  • Advanced Placement (AP)
  • SAT
  • Medicine
  • Law
  • Engineering
Bezzdna [24]
3 years ago
9

How would you prepare 2-methyl-2-propanol via a grignard with dimethyl carbonate as your carbonyl source? show all reagents?

Chemistry
1 answer:
Andreas93 [3]3 years ago
3 0

Answer:

React it with CH₃MgBr and work up the product with saturated ammonium chloride solution

Explanation:

Grignard reagents convert esters into tertiary alcohols.

The general equation is

\text{RCOOR}' \xrightarrow[\text{2. H}^{+}]{\text{1. R$^{\prime \prime}$MgBr}}\text{RR$_{2}^{\prime \prime}$C-OH}

The Grignard reagent in this synthesis is methylmagnesium bromide. You prepare it by reacting a solution methyl bromide in anhydrous ether with magnesium and a few crystals of iodine.

The reaction consumes 3 mol of CH₃MgBr per mole of dimethyl carbonate, and everything happens in the same pot.

Acid workup of the product usually involves the addition of a saturated aqueous solution of ammonium chloride and extraction with a low-boiling organic solvent.

The mechanism involves:

Step 1. Nucleophilic attack and loss of leaving group

(a) The Grignard reagent attacks the carbonyl of dimethyl carbonate, followed by (b) the loss of a methoxide leaving group.

Step 2. Nucleophilic attack and loss of leaving group

(a) A second mole of the Grignard reagent attacks the carbonyl of methyl acetate, followed by (b) the loss of a methoxide leaving group.

Step 3. Nucleophilic attack and protonation of the adduct.  

(a) A third mole of the Grignard reagent attacks the carbonyl of acetone, followed by (b) protonation of the alkoxide to form 2-methylpropan-2-ol.

You might be interested in
Why is it difficult for countries to reduce emissions of carbon dioxide
Natalka [10]

Answer:

Curbing global carbon dioxide emissions has been a challenge, primarily because they are being driven higher by countries with low per capita emissions.

Explanation:

"just trust me bro"

3 0
3 years ago
What type of rays result in shorter days? (science)
OLEGan [10]

Answer:

verical rays

Explanation:

4 0
2 years ago
Ni (s) + O2 (g) → NiO (s)
kicyunya [14]

Answer:

Explanation:

2NiS + 3O2 = 2NiO + 2SO2

3 0
3 years ago
Which solution has a molality of 0.25m nacl?
Solnce55 [7]

Molality can be expressed by moles of solute over kilograms of solvent. The question asks the molality of 0.25m NaCl. 0.25m NaCl is equal to 0.25 moles of NaCl over 1 kg of water.

5 0
3 years ago
Read 2 more answers
If the pH of a solution is 5.4 then the concentration of H+ ions is ___|_x10^-6
Svetllana [295]
H is 4*10^6 M , OH is 2.5*10^-9 M
6 0
3 years ago
Other questions:
  • What is the mass of the missing reactant in the following reactions, given that the reaction goes to completion? Do not include
    15·1 answer
  • A student prepares 150.0 mL of 1.40 M HCl using 35.0 mL of a stock solution. What is the concentration of the stock solution? Us
    5·1 answer
  • How many moles are in 1.204 x 10 to the 24th atoms of carbon
    13·1 answer
  • State the periodic law, and explain its relation to electron configuration. (Use Na and K in your explanation.)
    15·1 answer
  • A certain object has a volume of 25.0 ml and a mass of 100 g. what is the density of the object
    15·1 answer
  • A soccer player twists her ankle on the field. The atheltic trainer applies an ice bag with 260 g of ice inside. How much heat,
    12·1 answer
  • In IR spectroscopy, we normally talk about "frequencies" when in reality we are referring to wavenumbers. What is the mathematic
    14·1 answer
  • Which statement best describes heating by conduction?
    15·2 answers
  • When sodium atoms (Na) and chlorine atoms (CI) join to make
    7·2 answers
  • When an object such a a stone is dropped into water, it disturbs the surface of the water. Waves form at the surface of the wate
    12·1 answer
Add answer
Login
Not registered? Fast signup
Signup
Login Signup
Ask question!