Hydrogen bonds are most likely to exist between molecules of
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The strategy adopted for for the synthesis of <span>2-bromo-4-nitrobenzoic acid is as follow,
1) First Nitration of Toluene was done because the product formed (4-Nitrotoluene) will direct the next incoming electrophile (i.e. -Br) to ortho position with respect to -CH</span>₃ (ortho para directing) and at meta position with respect to -NO₂ (meta directing).
2) Bromination gave the exact desired product as discussed in point 1.
3) At last oxidation of toluene yield benzoic acid. No other substituent is oxidized other than -CH₃ group.
1) First Nitration of Toluene was done because the product formed (4-Nitrotoluene) will direct the next incoming electrophile (i.e. -Br) to ortho position with respect to -CH</span>₃ (ortho para directing) and at meta position with respect to -NO₂ (meta directing).
2) Bromination gave the exact desired product as discussed in point 1.
3) At last oxidation of toluene yield benzoic acid. No other substituent is oxidized other than -CH₃ group.