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katen-ka-za [31]
2 years ago
15

Arrange the events for the hydrolysis of amide bonds by chymotrypsin in their correct order 1) attack by Ser 195 to give a tetra

hedral intermediate 2) enzyme returns to initial state 3) protonation by His 57 and then cleavage of the C-N bond release the C-terminal fragment 4) protonation by His 57 and then cleavage of the C-O bond release the N-terminal fragment 5) attack by water, leading to formation of a tetrahedral intermediate 6) binding of substrate to properly position the scissile bond for cleavage O 6,2,4, 3, 1, 5 O 6, 1, 3, 5,4,2 O 6, 1,3,5,2,4 O 6, 1, 3,4, 5, 2
Chemistry
1 answer:
Tanzania [10]2 years ago
5 0

Answer:

6,1,3,5,4,2

Explanation:

Methods for the cleavage of highly stable amide bonds were developed to control their functions. One such method is the use of enzymes, which have active sites and binding pockets for specific amino acids, which is then followed by activation of amide bonds for hydrolysis. Chymotrypsin is one of the families of enzymes which hydrolyses amide bonds. Its catalytic site contains an oxyanion binding hole which consists of: Serine (Ser), Histidine (His) and Aspartic acid (Asp) triad. During catalysis, the triad works in a synergistic manner to break the amide bond. Firstly the side chain of Aspartic acid makes a hydrogen bond with Histidine, making it more nucleophilic. Secondly, His forms a strong hydrogen bond with the hydroxyl group of Ser and abstracts the proton from the hydroxyl group of Ser which in turn attacks the amide bond to form a tetrahedral transition state. This tetrahedral transition state collapses leading to the hydrolysis pf the amide bond by acid-base catalysis.

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Which of the following molecules would exhibit only London forces?a)CH4, BH3, and CCl4b)H2O, NH3, and CCl4c)PH3, NH3, and CCl4
Alex787 [66]

Answer:

a)CH₄, BH₃, and CCl₄

Explanation:

<u>London dispersion forces:- </u>

The bond for example, in the molecule is F-F, which is non-polar in nature because the two fluorine atoms have same electronegativity values.

The intermolecular force acting in the molecule are induced dipole-dipole forces or London Dispersion forces / van der Waals forces which are the weakest intermolecular force.

Out of the given options, H₂O , NH₃ exhibits hydrogen bonding which is:-

<u>Hydrogen bonding:- </u>

Hydrogen bonding is a special type of the dipole-dipole interaction and it occurs between hydrogen atom that is bonded to highly electronegative atom which is either fluorine, oxygen or nitrogen atom.

Thus option B and C rules out.

<u>Hence, the correct option which represents the molecules which would exhibit only London forces is:- a)CH₄, BH₃, and CCl₄</u>

4 0
3 years ago
Is carbon dioxide a polar molecule? Why or Why Not?
irinina [24]

Explanation:

Carbon dioxide isn't a polar molecule because

same nature of charge appears in opposite direction which cancel each other. So, carbon dioxide is non-polar molecule.

6 0
3 years ago
1. When an ionic bond forms between magnesium (Mg) and bromine (Br), which of the following occurs?
AleksAgata [21]

The correct answers are:

1. B. Mg loses two electrons.

When Mg and Br combine, 2 atoms of Br attaches itself to Mg. The chemical reaction is:

Mg + Br ---> MgBr2

Since Br is more electronegative than Mg, then Mg loses an electron per Br therefore losing 2 electrons.

 

2. D. An atom that gains electrons must be attracted to an atom that loses electrons.

An ionic bond is formed when one molecule is more electronegative than the other molecule which results in gaining and losing of electrons. The more electronegative molecule gains electron while the less electronegative loses electron.

8 0
2 years ago
Calculate the amount of C in 0.600g of CO2.
pashok25 [27]

Answer: Since one molecule of CO2 contains one molecule carbon atoms, therefore, 0.6 molecule of carbon dioxide will contain 0.6 molecule of carbon.

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Explanation

= No. Of molecule × molar mass

= 0.6× 12gm

=7.2gm

8 0
2 years ago
Help me please!!
Scrat [10]
I'm pretty sure it's D. Compounds
Salt water is an example of a solution, and a solution is a type of mixture, so by multiple choice logic none can be the right answer! Seriously though - mixture are combinations of two compounds that are physically combined but do not undergo a chemical reaction with one another to produce a new compound. For instance, when you dissolve salt in water, you don't produce any new products, and you can boil away the water to leave only the salt (a physical method of separation). You cannot separate a compound by physical means because by definition this would be a chemical reaction as you're breaking bonds.
7 0
3 years ago
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