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egoroff_w [7]
3 years ago
9

Mutations in genes encoding cell signaling proteins contribute to many cancers. For example, a chromosomal translocation fuses t

he Bcr gene to the Abl gene, leading to a constitutively active Bcr–Abl kinase and chronic myeloid leukemia (CML). CML is successfully treated with the drug imatinib (trade name Gleevec), which mimics an Abl kinase substrate and thus inhibits kinase activity. What normal cell molecule, and kinase substrate, does Gleevec mimic?
Chemistry
1 answer:
schepotkina [342]3 years ago
6 0

Imatinib is a small molecule kinase inhibitor. The BCR-ABL kinase can phosphorylate a series of downstream substrates, leading to proliferation of mature granulocytes. Bcr-Abl kinase substrate is the tyrosine. The Protein Tyrosine Kinase activity is an important requirement for malignant transformation, and that it cannot be complemented by any downstream effector, though not all interactions of BCR-ABL with other proteins are phosphotyrosine dependent.

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Plz help me woth these 2 questions they r killing me!!!!!
Bogdan [553]
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Yes, you could begin to swear because you are used to hearing those words so in your mind it will get implanted and it will be just a natural response.

Happy studying ^_^
3 0
3 years ago
Problem Page A chemist measures the amount of bromine liquid produced during an experiment. He finds that of bromine liquid is p
masha68 [24]

The question is incomplete, here is the complete question:

A chemist measures the amount of bromine liquid produced during an experiment. She finds that 766.g of bromine liquid is produced. Calculate the number of moles of bromine liquid produced. Round your answer to 3 significant digits.

<u>Answer:</u> The amount of liquid bromine produced is 4.79 moles.

<u>Explanation:</u>

To calculate the number of moles, we use the equation:

\text{Number of moles}=\frac{\text{Given mass}}{\text{Molar mass}}

We are given:

Given mass of liquid bromine = 766. g

Molar mass of liquid bromine, (Br_2) = 159.8 g/mol

Putting values in above equation, we get:

\text{Moles of liquid bromine}=\frac{766.g}{159.8g/mol}=4.79mol

Hence, the amount of liquid bromine produced is 4.79 moles.

6 0
3 years ago
Which line segment on the graph represents boiling
hoa [83]
1. There is no graph given

2. ENERGY LEVELS!!!

Boiling is the process of liquid(middle energy, flat line) turning into a gas(lots of energy, flat line), hope this helps
8 0
3 years ago
True or false natural elements don't reflect light.
Burka [1]
I think the statement is false. Natural elements do reflect light. Almost everything in this world reflect light. Reflection<span> is when </span>light<span> bounces off an object. Hope this answers the question. Have a nice day.</span>
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A 25.0 mL sample of 0.100 M lactic acid (HC3H503, Ka = 1.4 E-4) is titrated with 0.100 M NaOH solution. Calculate the pH of the
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I’m a bit confused too
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3 years ago
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