<h3><u>Full Question:</u></h3>
The following compound has been found effective in treating pain and inflammation (J. Med. Chem. 2007, 4222). Which sequence correctly ranks each carbonyl group in order of increasing reactivity toward nucleophilic addition?
A) 1 < 2 < 3
B) 2 < 3 < 1
C) 3 < 1 < 2
D) 1 < 3 < 2
<h3><u>Answer: </u></h3>
The rate of nucleophilic attack of carbonyl compounds is 2<3 <1.
Option B
<h3><u>Explanation. </u></h3>
Nucleophilic attack is explained as the attack of an electron rich radical to a carbonyl compound like aldehyde or a ketone. A nucleophile has a high electron density, so it searches for a electropositive atom where it can donate a portion of its electron density and become stable.
A carbonyl compound is a 
hybridized carbon atom with a double bonded oxygen atom in it. The oxygen atom pulls a huge portion of electron density from carbon being very electropositive.
In a ketone, there are two factors that make it less likely to undergo a nucleophilic attack than aldehyde. Firstly, the steric hindrance of two carbon groups being attached with the carbonyl carbon makes it harder for the nucleophile to approach. Secondly, the electron push by the carbon groups attached makes the carbonyl carbon a bit less electropositive than the aldehyde one. So aldehydes are more reactive towards a nucleophilic addition reaction.
Answer:
B
Explanation:
Boyle was known for rejecting Aristotle's theory basing it on the four elements (earth, air, fire, water).
To dissolve one substance, attractions between solute and solvent particles must be formed, steps involved are:
<h3><u>Formation of a solution:</u></h3>
- A physical process, not a chemical one, takes place when a solute and a solvent combine to produce a solution.
- In other words, by applying the right separation techniques, both the solute and the solvent may be recovered in chemically unaltered forms.
- It is claimed that two substances are entirely miscible when they combine to create a single homogenous phase in all ratios. Water and ethanol mix well, much like different gas combinations do.
- When two substances, like oil and water, are fundamentally insoluble in one another, they are said to be immiscible.
- We have already talked about several examples of gaseous solutions, such as the atmosphere of Earth.
- Thus, a system that has two or more compounds homogeneously (in a single phase) dissolved in it is called a solution. It is the homogenous mixture formed when a solute dissolves in a solvent.
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Answer:
False
Explanation:
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