The density<span> of a </span>substance<span> is the relationship between the mass of the substance </span><span>and how much space it takes up (volume). The mass of atoms, their size, and how they are arranged </span>determine<span> the </span>density<span> of a </span>substance<span>. </span>Density<span> equals the mass of the </span>substance<span> divided by its volume; D = m/v.</span>