The loss of matter is called the mass defect. The missing matter is converted into energy. You can actually calculate the amount of energy produced during a nuclear reaction with fairly simple equation developed by Albert Einstein; E = mc^2. In this equation, E is the amount of energy produced, m is the missing mass, or the mass defect, and c is the speed of light, which is a rather large number. The speed of light is squared, making that part of the equation a very large number that, even when multiplied by a small amount of mass, yields a large amount of energy.
The heart rate will likely decrease. As the cardiac muscle, or heart, gets stronger, it takes less effort to pump more blood. As a result, the heart will probably beat less, decreasing the heart rate. This is why athletes often have lower heart rates than the average person.
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