Barbiturates, including "truth serums" seen in movies like Meet the Fockers and sedatives that may have led to the untimely deat
h of Jimi Hendrix, are often synthesized using what type of reaction sequence involving two consecutive enolate alkylations
1 answer:
Answer:
Explanation:
Diethyl malonate is more acidic than monocarbonyl compounds (pKa=13) due to their alpha hydrogens being attached to two carbonyl groups. Thus, the <u>malonic ester is easily converted to its enolate ion by reaction with sodium ethoxide in ethanol</u>. The product of the alkylation of the malonic ester leaves a <u>hydrogen atom acid in an alpha position</u>, so the alkylation process can be repeated a second time to produce a dialkylated malonic ester.
In this case, when urea is treated with diethyl malonate in the presence of sodium ethoxide base,<u> the second alkylation step occurs intramolecularly</u> to generate a cyclic product, barbituric acid.
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Answer:
NH3>H2O>Cl-
Explanation:
The given wavelengths of maximum absorption for each complex can be used to estimate the magnitude of field splitting of the respective ligands as shown in the image attached. The field splitting is reported in the unit kilojoule per mole (KJmol-1).
It can be seen from the calculation in the image attached that ammonia shows the highest crystal field splitting followed by water and lastly the chloride anion. This corresponds to the respective positions of these species in the spectrochemical series. Water and the chloride ion are weak field ligands.
