Question

Lipoamide is a covalently attached coenzyme that plays a key role in several decarboxylase reactions, including glycine decarboxylase, and is attached to a lysine residue in the enzyme.
Review the molecule again. Manipulate it in order to identify the specific lysine residue that serves as the attachment site for lipoamide in the enzyme glycine decarboxylase. You may want to view the hint if you need help.

Choose one:
A. Lysine 17
B. Lysine 8
C. Lysine 118
D. Lysine 63

Answer 1

Answer:

Lysine 63.

Explanation:

The coenzyme may be defined as the non protein part of an enzyme that plays an important role in the enzyme functioning. Any cation or small molecule like amino acids can acts as coenzyme.

Lipoamide is important coenzyme that plays an important role in the metabolic pathways by undergoes the decarboxylation reactions. The reduced lipoamide known as dihydrolipoamide is used for the covalent attachment at Lysine 63 residues.

Thus, the correct answer is option (D).