Basically stoichiometry is the measurement of elements, that is, the study of chemical quantities consumed or produced in a chemical reaction. When we are performing it we are using a special chemical counting unit: the mole, a unit of measurement, and one mole of a substance contains 6.022 * 10^23 particles. Now mole ratio is defined as the ratio of moles of one substance to the moles of another substance in a balanced equation. <span>If we are looking for the mole ratio between two substances, we need to look at the balanced equations</span> for the coefficients in front of the substances you are interested in.
This should be your guiding mantra for doing stoichiometry problems!
Answer: Extracellular [Ca2+]
Explanation:
The sensitivity and density of the alpha receptors serve to <em>enhance the response to the release of</em> <em>norepinephrine (NE)</em> . However, they do not exert a strong influence as the concentration of calcium ions on the amount of <em>norepinephrine (NE)</em> released by sympathic nerve terminals.
The release of neurotransmitters depends more on either an external or internal stimulus.This results in an action potential which on reaching a nerve terminal, results in the opening of Ca²⁺ channels in the neuronal membrane. Because the extracellular concentration of Ca²⁺ is greater than the intracellular Ca²⁺ concentration, Ca²⁺ flows into the nerve terminal. This triggers a series of events that cause the vesicles containing <em>norepinephrine (NE)</em> to fuse with the plasma membrane and release <em>norepinephrine (NE)</em> into the synapse. The higher the action potential, the higher the Ca²⁺ flow into the terminals resulting in higher amount of <em>norepinephrine (NE)</em> into the synapse, and vice versa.
Catechol-O-methyltransferase (COMT) is one of several enzymes that degrade catecholamines such as dopamine, epinephrine, and norepinephrine. It serves a regulatory purpose to lower the concentration of norepinephrine upon its release from nerve terminals.
