The single most important chemical weathering agent is Carbon dioxide.
Weathering refers to the process that change the physical and chemical character of rock at or near the surface. Weathering has a dramatic impact on the composition of Earth's atmosphere. Chemical weathering removes carbon dioxide from the atmosphere, allowing it to be transformed into limestone and stored in the crust. Without chemical weathering, the elevated levels of carbon dioxide in the atmosphere would have long made Earth too hot to sustain life.
Answer:

Explanation:
At constant pressure Thermal energy always moves from a greater energy level to a lesser energy level, laws of thermodynamics prove that.
Nature always likes to attain equilibrium either it's movement of heat energy or flow of water from higher region to lower region. The first and second law of thermodynamics are profe of that, the first law says that the total energy of universe is Constant. Energy can not be destroyed it always changes from one form to another, by work and heat. The second law explains why thermal energy moves from a greater energy level to a lesser energy level, it deals with the change in entropy of a system and surrounding and states heat flows from hot environment to cold environment.
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The answers the best fit the blank provided above are the terms NICOTINE and ALCOHOL. This is related to the discussion above Drug use and abuse. Both of these results in clearly dangerous psychoactive chemicals. Hope this answers your question. Have a great day!