There are several scientific aspects that require to be comprehended beforehand;
Force = mass * acceleration
Weight = mass * gravity (10m/s)
Momentum = mass * velocity
Inertia is a property of mass which is the tendency of an object to remain at constant velocity unless acted upon by an outside force.
Based on these formulae, it is evident that if the 220lb player and 288lb player are moving at the same velocity, the 288lb player has more inertia and momentum than the 22olb. Therefore, it would require more force (hence energy) to change the direction or the speed (in tackling) of the player with 288lb compared with what would be required on the 220lb player.