Endothermic reaction : When two liquids are combine into a flask, then the flask feels cold when we touch it because the system absorbed heat from the surrounding.
In general, endothermic process absorbs heat and cool the surrounding.
Exothermic reaction : When two liquids are combine into a flask, then the flask feels hot when we touch it because the system released heat into the surrounding.
In general, exothermic process releases heat and rise the temperature of surrounding.
Answer: Only non-polar medicines can diffuse across the membrane. non-polar drugs are lipid soluble, while polar drugs are water soluble, so polar drugs cant absorb through biological membranes.