TCP/IP, or the Transmission Control Protocol/Internet Protocol, is a suite of communication protocols used to interconnect network devices on the internet. TCP/IP can also be used as a communications protocol in a private network (an intranet or an extranet).
The sequence number in a header is used to keep track of which segment out of many this particular segment might be. The next field, the acknowledgment number, is a lot like the sequence number. The acknowledgment number is the number of the next expected segment.
The 32 bit sequence number field defines the number assigned to the first byte of data contained in this segment. TCP is a stream transport protocol. To ensure connectivity, each byte to be transmitted is numbered.